Global Kinase Inhibitors Market– Overview
Kinase inhibitors are the type of enzyme inhibitors that specifically block the action of one or more protein kinases. Protein kinase is the enzyme that adds a phosphate group to a protein and the process is called phosphorylation. They are intracellular and cell surface proteins that play a critical role in cell signaling pathways which are involved in metabolism, adaptation, growth and differentiation, and metabolism. The phosphate groups are added to serine, tyrosine, or threonine amino acids on the protein. Dual specificity kinase often acts on all three. Phosphorylation regulates many biological processes. Therefore, protein kinase inhibitors are used to treat the disease which is caused due to hyperactive protein kinase which includes mutant and overexpressed kinase in the case of cancer. Kinase inhibitors can also modulate the cell functions to overcome other disease-causing drivers. The first tyrosine kinase inhibitor was imatinib, which was used to treat Philadelphia chromosome-positive chronic lymphocytic leukemia.
Most kinase inhibitors are antineoplastic agents, some are also used for conditions like macular degeneration, rheumatoid arthritis, and idiopathic pulmonary fibrosis. Tyrosine kinase is the main regulator of cellular processes and has many roles in the pathophysiology of many diseases. Tyrosine kinase inhibitors are used in precision oncology. The effectiveness of the kinase inhibitors may vary from patient to patient. Tyrosine kinase inhibitors are used to treat many types of cancer which include, gastrointestinal stromal tumors, Waldenstrom macroglobulinemia, kidney cancer, chronic lymphatic leukemia, chronic myeloid leukemia, brain metastatic breast cancer, and HER2-positive breast cancer. There are approximately 50 drugs belonging to the tyrosine kinase inhibitors which are approved by the US Food and Drug Administration. The type of medication depends on the genetic characteristics of the cancer the patient has and the stage of the cancer.
Global Kinase Inhibitors Market– Competitive Insight
In April 2024, Deciphera Pharmaceuticals to be acquired by ONO Pharmaceutical for USD 2.4 Billion.
In June 2022, Bristol-Myers Squibb bought turning-to-buy turning point therapeutics for USD 4.1 billion.
In Dec 2019, Theravance Biopharma and Pfizer Inc. entered into a global license agreement for the skin-targeted, locally acting Pan-Janus Kinas inhibitor program.
Some of the Key Players in the Global Kinase Inhibitors Market Include –
Global Kinase Inhibitors Market– Growth Drivers
There has been an increase in the prevalence of cancer all over the world. According to data by WHO, in the year 2022, there were 20 million new cases of cancer throughout the world. About 9.7 million deaths were reported in the same year. About 1 in every 5 people develops cancer in their lifetime. Thus, the increase in the cases of cancer all over the world has become a major concern. Thus, the use of kinase inhibitors in the treatment has been on the rise in recent years. Therefore, the growth in the prevalence of cancer cases is one of the growth drivers for the global kinase inhibitor market. Nowadays there has been a rise in the advancements in the targeted therapies associated with kinase inhibitors for the treatment of the cancer, thus making it another prominent market driver. Kinase inhibitors have uses like treatment in the inflammatory devices and even metabolic devices. Thus the increase in the use of kinase inhibitors in the treatment of these complications rather than cancer is also driving the market forward. Again, increases in the research and development in the case of kinase inhibitors are driving the market forward. An increase in the investment in research and development in the particular segment is also driving the global kinase inhibitor market. In recent years, there has also been an increase in the launch of products related to kinase inhibitors in the market.
Global Kinase Inhibitors Market– Restraints
The global restraints for the kinase inhibitor market include the high cost of the treatment in the case of the use of kinase inhibitors in the treatment of cancer. All cancer patients cannot afford the treatment for the same and thus may act as the market restrain for the same market. Apart from its uses, kinase inhibitors may have many side effects. For example, tyrosine kinase and Janus kinase are targeted therapies in the treatment of cancer but are associated with side effects like diarrhea, nausea, vomiting, fluid buildup, fatigue, fever, and weight loss. Again kinase inhibitors may also cause hypertension and impaired wound healing. Thus the side effects associated with the use of the kinase inhibitors act as the major market restrain thus hindering the growth of the particular market. High competition in the current market can act as another market restraint for the kinase inhibitor market.
Global Kinase Inhibitors Market– Opportunities
An increase in the research and development of kinase inhibitors provides further opportunities for companies to invest and grow in a particular market. An increase in the cases of chronic diseases like cancer also provides opportunities for growth in the global kinase inhibitors market. According to the Global Burden Report and a report by WHO, one in every five people in the world is likely to develop cancer in his lifetime, thus the increase in the cases of cancer will always provide opportunities for growth in the particular market. A rise in awareness among the people about the use of the kinase inhibitors in case of treatment in the cancer can also be an opportunity for the growth in the particular market.
Global Kinase Inhibitors Market– Geographical Insight
The market for kinase inhibitors is segmented into regions such as North America, Latin America, Europe, Asia-Pacific, the Middle East & Africa. North America is the largest market for kinase inhibitors due to the presence of advanced technologies in the region. The presence of key market players contributes to research and development in the region. Europe is another prominent market for kinase inhibitors. The Asia Pacific region is showing considerable growth prospects. The market is further propelled by advancements in technology and infrastructure development. Africa is an emerging market for the sales of kinase inhibitors. The investments in healthcare and technologies are paving the way for market growth opportunities.
Global Kinase Inhibitors Market– Key Development
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