Demoid tumors are mesenchymal neoplasms that are considered locally invasive but non-metastasizing. They are also known as aggressive fibromatosis, deep fibromatosis, deep fibromatosis, and musculoaponeurotic fibromatosis. Even though they do not metastasize, they are locally invasive and cause significant morbidity and mortality. Desmoid tumor is primarily treated with surgery with or without radiation therapy. Despite surgical resection, DTs have a high rate of local recurrence, and hence they have been labeled as intermediate locally aggressive tumors by the World Health Organization. According to the World Health Organization, desmoid tumor is clonal fibroblastic proliferation that arises in the deep soft tissues and is characterized by infiltrative growth and a tendency toward local recurrence but an inability to metastasize even though it may be multifocal in the same limb or body part.
The etiology of DT is unknown. Most desmoid tumor occurs sporadically, and 85% have a mutation in the CTNNB1 encoding beta-catenin pathway. The three distinct mutations identified 41A, 45F, and 45. Mutation 45F is associated with a high risk of recurrence. The desmoid tumor is seen at increased frequency in familial adenomatous polyposis, mostly abdominal FAP caused by a mutation in the surgery in the APC gene. Desmoid tumor arising in FAP has a predilection for the prior surgical site, and previous surgery is a risk factor.
Global Desmoid Tumors Market – Competitive Landscape
On February 16, 2021, Iterion Therapeutics secured USD 17 million to advance the development of Tegavivint in multiple tumor settings. Companies investing continuously in the desmoid tumor market.
Some of the Key Players in the Global Desmoid Tumors Market Include –
Global Desmoid Tumors Market – Growth Drivers
Continued advancements in diagnostics technologies contribute to the early and accurate detection of desmoid tumors, facilitating prompt intervention and treatment, and thereby driving market growth. According to the National Center for Biotechnology Information (NCBI), the global incidence of desmoid tumors is approximately 3-5 cases per million person-years. Significant investments in research and development activities by pharmaceutical companies and biotechnology firms fuel the discovery of innovative therapies and treatment modalities for desmoid tumors fostering market growth. The development of targeted therapies specific to the molecular characteristics of desmoid tumors offers more precise and effective treatment options, contributing to the growth of the market. Growing awareness among healthcare professionals and the general public about desmoid tumors leads to increased early diagnosis and intervention, creating a demand for therapeutic solutions and positively impacting market growth. Collaborations between pharmaceutical companies, research institutions, and advocacy groups enhance research capabilities, accelerate clinical trials, and contribute to the development of new therapeutic options for desmoid tumors. Regulatory incentives and orphan drug designations present opportunities for accelerated development and approval of novel desmoid tumor treatments, attracting investment and fostering innovation. Exploring untapped regions, especially in emerging markets, provides opportunities for market expansion, where increasing healthcare infrastructure and awareness may drive the demand for desmoid tumor treatments. A shift towards patient-centric healthcare models encourages the development of tailored treatment approaches for desmoid tumor patients, addressing individual needs and improving overall treatment outcomes.
Global Desmoid Tumors Market – Restraints
The global desmoid tumors market faces challenges due to a limited number of approved treatment options, creating a gap in comprehensive therapeutic choices for patients. The intricate and heterogeneous nature of desmoid tumors’ biology poses challenges in developing targeted therapies, hindering the development of effective and universally applicable treatments. Limited awareness among healthcare professionals and the general public about desmoid tumors contributes to delayed diagnosis and intervention, impacting the timely initiation of appropriate treatments. The rare occurrence of desmoid tumors results in relatively small patient populations, making it less attractive for pharmaceutical companies to invest in research and development compared to more developed to more prevalent conditions. The high costs associated with the research and development of new desmoid tumor treatments create a financial barrier for pharmaceutical companies, potentially limiting investment in innovative therapies. According to National Center for Biotechnology Information (NCBI), the cost of desmoid tumors is USD 473,697. The absence of standardized treatment protocols for desmoid tumors leads to variability in clinical approaches, creating challenges in establishing consistent and effective therapeutic interventions. Difficulty in recruiting a sufficient number of patients for clinical trials due to the rarity of desmoid tumors can result in prolonged trial durations slowing down the development of new treatments. Safety concerns and potential side effects associated with desmoid tumor treatments may impact patient acceptance and adherence, limiting the widespread adoption of certain therapies.
Global Desmoid Tumors Market – Geographical Insight
The market for desmoid tumors is segmented into the regions of North America, Latin America, Europe, the Middle East, and Africa. North America is the largest market for desmoid tumors due to advanced healthcare infrastructure, high prevalence of the disease, and ongoing research initiatives. Europe plays a crucial role in the desmoid tumors market, with countries like Germany, France, and the UK contributing to the market growth due to well-established healthcare systems and research capabilities. The Asia-Pacific region is witnessing growth in the desmoid tumors market, fueled by a rising prevalence of the disease, increasing healthcare investment, and a focus on improving access to advanced medical treatment.
Global Desmoid Tumors Market – Opportunities
Opportunities arise in the development of biosimilars for desmoid tumor treatments, prompting competition, affordability, and increased accessibility for patients. Establishing patient advocacy and education programs presents opportunities to raise awareness, promote early diagnosis, and empower desmoid tumor patients in their treatment journey. Regulatory incentives for orphan drug designations present opportunities for accelerated development and approval of novel desmoid tumor treatments, attracting investment and fostering innovation. Given the rarity of pediatric desmoid tumors, opportunities exist for research and development specifically targeting this patient population, addressing their unique needs and challenges.
Global Desmoid Tumors Market – Key development
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