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Cognitive Impairment in Parkinson's Disease & Dementia Market - Global Industry, Analysis, Size, Share, Growth, Trends, and Forecasts 2023-2030

Parkinson’s is a neuro vegetative disorder that predominantly affects dopamine-producing neurons of the substantia nigra, resulting in motor symptoms. Parkinson’s disease is a heterogeneous multisystem disorder comprising a wide range of motor and non-motor symptoms. These non-motor symptoms are frequent and become increasingly prevalent with advancing disease. Cognitive decline is among the most common non-motor symptoms. As one of the most severe and disabling non-motor symptoms of Parkinson’s disease, cognitive impairment, particularly dementia, has been statistically associated with mortality. Cognitive impairment impairs social function and intensifies the caregiver burden and cost of disease-related medical care. The pathophysiology of cognitive impairment in Parkinson’s disease is complex and likely involves a disruption of multiple distinct neural networks occurring over time. The timing, profile, and rate of cognitive impairment in Parkinson’s disease as well as risk factors for developing these cognitive changes.

The cognitive profile in Parkinson’s disease can range from normal cognition to mild cognitive impairment and eventually dementia. The neurodegenerative process underlying Parkinson’s disease starts long before the onset of motor symptoms, and cognitive changes can occur during these earlier phases of neurodegeneration. The presence of dementia before or close to the onset of parkinsonism is more suggestive of a clinical diagnosis of dementia with Lewy bodies. Different neuropsychological tests and norms are across centers and for different research studies and clinical assessments. Functioning in instrumental daily life activities will help to reach more reliable conclusions about their cognitive status.

Global Cognitive Impairment in Parkinson’s Disease & Dementia Market – Competitive Landscape

On November 29, 2023, Photopharmics raised USD 16 million in investment led by Kickstart. On June 22, 2023, Amyloid disease therapy diagnostics developer AltPep raised USD 53 million in a series B round. On June 22, 2023, a Biotech startup developing tests and treatments for Parkinson’s disease raised USD 52.9 million. On June 19, 2023, Koneksa and Beacon Biosignals joined forces on neuro biomarkers. On March 30, 2022, Altoida upsized its series A round to USD 20.3 million to advance its first-in-class AI-powered neurocognitive disorders. On July 8, 2021, GSK invested in Alector’s antibodies for neurodegenerative disease.

Some of the Key Players in the Global Cognitive Impairment in Parkinson’s Disease & Dementia Market Include –

  • Pfizer
  • Novartis
  • Eli Lily
  • Janssen Pharmaceutical Inc
  • Biogen pharmaceuticals
  • Forest Laboratories
  • Sanofi S.A.
  • AstraZeneca

Global Cognitive Impairment in Parkinson’s Disease & Dementia Market – Growth Drivers

The prevalence rate of Parkinson’s disease and dementia are the growth factor for this market. According to the World Health Organization, the prevalence of Parkinson’s disease has doubled in the past 25 years. In year 2019 global estimates showed USD 8.5 million individuals with Parkinson’s disease and more than USD 55 million people have dementia worldwide. The global rise in the aging population contributes significantly to the growth of the cognitive impairment market in Parkinson’s disease and dementia, as these conditions are more prevalent among the elderly. Growing awareness about cognitive impairments associated with Parkinson’s disease and dementia leads to early diagnosis and treatment, driving market growth. Ongoing advancements in diagnostic technologies enable more accurate and timely identification of cognitive impairments, fostering market expansion. Increased investment in research and development for effective treatments and therapies enhances the market’s growth by providing innovative solutions for cognitive impairment in Parkinson’s disease and dementia. Collaboration between pharmaceutical companies, research institutions, and healthcare organizations facilitates the development and commercialization of new drugs and therapies, stimulating market growth. Supportive government initiatives and funding for neuroscience research and treatment programs contribute to the growth of the cognitive impairment market. Globally increasing healthcare expenditure allows for greater accessibility to diagnostic tools, medications, and treatments for cognitive impairments associated with Parkinson’s disease and dementia. Integration of technology, such as telemedicine and remote monitoring, improves patient care and access to cognitive impairment interventions fostering market expansion.

Global Cognitive Impairment in Parkinson’s Disease & Dementia Market – Restraints

The cognitive impairment market in Parkinson’s disease and dementia faces constraints due to a lack of definitive treatment options for Parkinson’s disease and dementia, limiting the ability to address the root cause of cognitive decline effectively. The high cost associated with research and development and clinical trials for cognitive impairment treatments poses a significant restraint, potentially limiting the availability of affordable solutions. According to the National Center for Biotechnology Information (NCBI), the treatment cost per patient is approximately USD 37, 481 Stringent regulatory requirements and lengthy approval processes for new drugs and therapies can impede market growth by delaying the introduction of innovative treatments to the market. The stigma surrounding cognitive impairments and a general lack of awareness can result in delayed diagnosis and treatment, hindering the market’s potential for early intervention and management. Adverse side effects with certain medications used in the treatment of cognitive impairment may lead to patient reluctance, impacting adherence to prescribed therapies and limiting market growth. Ethical considerations related to clinical trials and research involving vulnerable populations, such as those with cognitive impairments, can pose challenges and slow down the pace of advancements in the field. Disparities in healthcare access, especially in lower-income regions, may limit the reach of cognitive impairment interventions, hindering market growth in certain technologies.

Global Cognitive Impairment in Parkinson’s Disease & Dementia Market – Opportunities

Opportunities arise with the ongoing developments in precision medicine, allowing for personalized treatment approaches tailored to the specific characteristics of individuals with cognitive impairments in Parkinson’s disease and dementia. The identification of novel biomarkers presents opportunities for early and accurate diagnosis, enabling timely intervention and treatment in the cognitive impairment Parkinson’s disease and dementia market. The integration of digital health solutions, such as mobile apps and wearable devices, provides opportunities for remote monitoring. Patient engagement, real-time data collection in the management of cognitive impairment in Parkinson’s disease and dementia market.

Global Cognitive Impairment in Parkinson’s Disease & Dementia Market – Geographical Insight

The market for cognitive impairment in Parkinson’s disease and dementia is segmented into regions such as North America, Latin America, Europe, Asia-Pacific, the Middle East & Africa. North America is the largest market for cognitive impairment in Parkinson’s disease and dementia due to the high prevalence of Parkinson’s disease and dementia, well-established healthcare infrastructure, and substantial investment in research and development. European countries contribute significantly to the market, with increasing awareness, advanced healthcare systems, and rising aging populations, creating a conducive environment for the growth of cognitive impairment interventions. The Asia-Pacific region presents substantial growth opportunities, fueled by a large elderly population, changing demographics, and improving healthcare access, leading to increased demand for cognitive impairment solutions.

Global Cognitive Impairment in Parkinson’s Disease & Dementia Market – Key Development

  • On May 3, 2023, Lilly’s Donanemab significantly slowed cognitive and functional decline in a phase 3 study of Alzheimer’s disease
  • On April 25, 2022, NTU launched a center to study how dementia develops in Asians.
  • On February 27, 2023, Aptinyx Inc. reported results from a phase 2 study of NYX-458 in cognitive impairment associated with Parkinson’s disease and dementia with Lewy bodies.
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Research Methodology: Aspects

Market research is a crucial tool for organizations aiming to navigate the dynamic landscape of customer preferences, business trends, and competitive landscapes. At Cognizance Market Research, acknowledging the importance of robust research methodologies is vital to delivering actionable insights to our clientele. The significance of such methodologies lies in their capability to offer clarity in complexity, guiding strategic management with realistic evidence rather than speculation. Our clientele seek insights that excel superficial observations, reaching deep into the details of consumer behaviours, market dynamics, and evolving opportunities. These insights serve as the basis upon which businesses craft tailored approaches, optimize product offerings, and gain a competitive edge in an ever-growing marketplace.

The frequency of information updates is a cornerstone of our commitment to providing timely, relevant, and accurate insights. Cognizance Market Research adheres to a rigorous schedule of data collection, analysis, and distribution to ensure that our reports reflect the most current market realities. This proactive approach enables our clients to stay ahead of the curve, capitalize on emerging trends, and mitigate risks associated with outdated information.

Our research process is characterized by meticulous attention to detail and methodological rigor. It begins with a comprehensive understanding of client objectives, industry dynamics, and research scope. Leveraging a combination of primary and secondary research methodologies, we gather data from diverse sources including surveys, interviews, industry reports, and proprietary databases. Rigorous data analysis techniques are then employed to derive meaningful insights, identify patterns, and uncover actionable recommendations. Throughout the process, we remain vigilant in upholding the highest standards of data integrity, ensuring that our findings are robust, reliable, and actionable.

Key phases involved in in our research process are mentioned below:


Understanding Clients’ Objectives:

Extensive Discussions and Consultations:

  • We initiate in-depth discussions and consultations with our clients to gain a comprehensive understanding of their objectives. This involves actively listening to their needs, concerns, and aspirations regarding the research project.
  • Through these interactions, we aim to uncover the underlying motivations driving their research requirements and the specific outcomes they hope to achieve.

Industry and Market Segment Analysis:

  • We invest time and effort in comprehensively understanding our clients’ industry and market segment. This involves conducting thorough research into market trends, competitive dynamics, regulatory frameworks, and emerging opportunities or threats.
  • By acquiring a deep understanding of the broader industry landscape, we can provide context-rich insights that resonate with our clients’ strategic objectives.

Target Audience Understanding:

  • We analyze our clients’ target audience demographics, behaviors, preferences, and needs to align our research efforts with their consumer-centric objectives. This entails segmenting the audience based on various criteria such as age, gender, income level, geographic location, and psychographic factors.
  • By understanding the nuances of the target audience, we can tailor our research methodologies to gather relevant data that illuminates consumer perceptions, attitudes, and purchase intent.


Identifying Challenges and Opportunities:

  • We proactively identify the challenges and opportunities facing our clients within their respective industries. This involves conducting SWOT (Strengths, Weaknesses, Opportunities, Threats) analyses and competitive benchmarking exercises.
  • By identifying potential obstacles and growth drivers, we can provide strategic recommendations that help our clients navigate complexities and capitalize on emerging opportunities effectively.

Grasping Specific Goals:

  • We delve into the intricacies of our clients’ objectives to gain clarity on the specific goals they aim to accomplish through the research. This entails understanding their desired outcomes, such as market expansion, product development, or competitive analysis.
  • By gaining a nuanced understanding of our clients’ goals, we can tailor our research approach to address their unique challenges and opportunities effectively.

Data Collection:


Primary Research Process:

  • Surveys: We design and administer surveys tailored to capture specific information relevant to our clients’ objectives. This may involve employing various survey methodologies, such as online, telephone, or face-to-face interviews, to reach target audiences effectively.
  • Interviews: We conduct structured or semi-structured interviews with key stakeholders, industry experts, or target consumers to gather in-depth insights and perspectives on relevant topics. These interviews allow us to probe deeper into specific issues and uncover valuable qualitative data.
  • Focus Groups: We organize focus group discussions with carefully selected participants to facilitate interactive discussions and gather collective opinions, attitudes, and preferences. This qualitative research method provides rich contextual insights into consumer behaviors and perceptions.
  • Observations: We conduct observational research by directly observing consumer behaviors, interactions, and experiences in real-world settings. This method enables us to gather objective data on consumer actions and reactions without relying on self-reported information.

Secondary Research Process:

  • Literature Review: We conduct comprehensive literature reviews to identify existing studies, academic articles, and industry reports relevant to the research topic. This helps us gain insights into previous research findings, theoretical frameworks, and best practices.
  • Industry Reports: We analyze industry reports published by reputable trade associations (whitepapers, research studies, etc.), and government agencies (U.S. Census Bureau, Bureau of Labor Statistics, and Securities and Exchange Commission etc.) to obtain macro-level insights into market trends, competitive landscapes, and industry dynamics.
  • Government Publications: We review government publications, such as economic reports, regulatory documents, and statistical databases, to gather relevant data on demographics, market size, consumer spending patterns, and regulatory frameworks.
  • Online Databases: We leverage online databases, such as industry portals, and academic repositories (PubMed Central (PMC), ScienceDirect, SSRN (Social Science Research Network), Directory of Open Access Journals (DOAJ), NCBI, etc.), to access a wide range of secondary data sources, including market statistics, financial data, and industry analyses.



Data Analysis:

The data analysis phase serves as a critical juncture where raw data is transformed into actionable insights that inform strategic decision-making. Through the utilization of analytical methods such as statistical analysis and qualitative techniques like thematic coding, we uncover patterns, correlations, and trends within the data. By ensuring the integrity and validity of our findings, we strive to provide clients with accurate and reliable insights that accurately reflect the realities of the market landscape.


Transformation of Raw Data:

  • Upon collecting the necessary data, we transition into the data analysis phase, where raw data is processed and transformed into actionable insights. This involves organizing, cleaning, and structuring the data to prepare it for analysis.

Utilization of Analytical Methods:

  • Depending on the research objectives, we employ a diverse range of analytical methods to extract meaningful insights from the data. These methods include statistical analysis, trend analysis, regression analysis, and qualitative coding.

Statistical Analysis:

  • Statistical tools are instrumental in uncovering patterns, correlations, and trends within the data. By applying statistical techniques such as descriptive statistics, hypothesis testing, and multivariate analysis, we can discern relationships and derive valuable insights.

Qualitative Analysis Techniques:

  • In addition to quantitative analysis, we leverage qualitative analysis techniques to gain deeper insights from qualitative data sources such as interviews or open-ended survey responses. One such technique is thematic coding, which involves systematically categorizing and interpreting themes or patterns within qualitative data.

Integrity and Validity Maintenance:

  • Throughout the analysis process, we maintain a steadfast commitment to upholding the integrity and validity of our findings. This entails rigorous adherence to established methodologies, transparency in data handling, and thorough validation of analytical outcomes.

Data Validation:

The final phase of our research methodology is data validation, which is essential for ensuring the reliability and credibility of our findings. Validation involves scrutinizing the collected data to identify any inconsistencies, errors, or biases that may have crept in during the research process. We employ various validation techniques, including cross-referencing data from multiple sources, conducting validity checks on survey instruments, and seeking feedback from independent experts or peer reviewers. Additionally, we leverage internal quality assurance protocols to verify the accuracy and integrity of our analysis. By subjecting our findings to rigorous validation procedures, we instill confidence in our clients that the insights they receive are robust, reliable, and trustworthy.


Importance of Data Validation:

  • Data validation is the final phase of the research methodology, crucial for ensuring the reliability and credibility of the findings. It involves a systematic process of reviewing and verifying the collected data to detect any inconsistencies, errors, or biases.

Scrutiny of Collected Data:

  • The validation process begins with a thorough scrutiny of the collected data to identify any discrepancies or anomalies. This entails comparing data points, checking for outliers, and verifying the accuracy of data entries against the original sources.

Validation Techniques:

  • Various validation techniques are employed to ensure the accuracy and integrity of the data. These include cross-referencing data from multiple sources to corroborate findings, conducting validity checks on survey instruments to assess the reliability of responses, and seeking feedback from independent experts or peer reviewers to validate the interpretation of results.

Internal Quality Assurance Protocols:

  • In addition to external validation measures, internal quality assurance protocols are implemented to further validate the accuracy of the analysis. This may involve conducting internal audits, peer reviews, or data validation checks to ensure that the research process adheres to established standards and guidelines.
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