Parkinson’s is a neuro vegetative disorder that predominantly affects dopamine-producing neurons of the substantia nigra, resulting in motor symptoms. Parkinson’s disease is a heterogeneous multisystem disorder comprising a wide range of motor and non-motor symptoms. These non-motor symptoms are frequent and become increasingly prevalent with advancing disease. Cognitive decline is among the most common non-motor symptoms. As one of the most severe and disabling non-motor symptoms of Parkinson’s disease, cognitive impairment, particularly dementia, has been statistically associated with mortality. Cognitive impairment impairs social function and intensifies the caregiver burden and cost of disease-related medical care. The pathophysiology of cognitive impairment in Parkinson’s disease is complex and likely involves a disruption of multiple distinct neural networks occurring over time. The timing, profile, and rate of cognitive impairment in Parkinson’s disease as well as risk factors for developing these cognitive changes.
The cognitive profile in Parkinson’s disease can range from normal cognition to mild cognitive impairment and eventually dementia. The neurodegenerative process underlying Parkinson’s disease starts long before the onset of motor symptoms, and cognitive changes can occur during these earlier phases of neurodegeneration. The presence of dementia before or close to the onset of parkinsonism is more suggestive of a clinical diagnosis of dementia with Lewy bodies. Different neuropsychological tests and norms are across centers and for different research studies and clinical assessments. Functioning in instrumental daily life activities will help to reach more reliable conclusions about their cognitive status.
Global Cognitive Impairment in Parkinson’s Disease & Dementia Market – Competitive Landscape
On November 29, 2023, Photopharmics raised USD 16 million in investment led by Kickstart. On June 22, 2023, Amyloid disease therapy diagnostics developer AltPep raised USD 53 million in a series B round. On June 22, 2023, a Biotech startup developing tests and treatments for Parkinson’s disease raised USD 52.9 million. On June 19, 2023, Koneksa and Beacon Biosignals joined forces on neuro biomarkers. On March 30, 2022, Altoida upsized its series A round to USD 20.3 million to advance its first-in-class AI-powered neurocognitive disorders. On July 8, 2021, GSK invested in Alector’s antibodies for neurodegenerative disease.
Some of the Key Players in the Global Cognitive Impairment in Parkinson’s Disease & Dementia Market Include –
Global Cognitive Impairment in Parkinson’s Disease & Dementia Market – Growth Drivers
The prevalence rate of Parkinson’s disease and dementia are the growth factor for this market. According to the World Health Organization, the prevalence of Parkinson’s disease has doubled in the past 25 years. In year 2019 global estimates showed USD 8.5 million individuals with Parkinson’s disease and more than USD 55 million people have dementia worldwide. The global rise in the aging population contributes significantly to the growth of the cognitive impairment market in Parkinson’s disease and dementia, as these conditions are more prevalent among the elderly. Growing awareness about cognitive impairments associated with Parkinson’s disease and dementia leads to early diagnosis and treatment, driving market growth. Ongoing advancements in diagnostic technologies enable more accurate and timely identification of cognitive impairments, fostering market expansion. Increased investment in research and development for effective treatments and therapies enhances the market’s growth by providing innovative solutions for cognitive impairment in Parkinson’s disease and dementia. Collaboration between pharmaceutical companies, research institutions, and healthcare organizations facilitates the development and commercialization of new drugs and therapies, stimulating market growth. Supportive government initiatives and funding for neuroscience research and treatment programs contribute to the growth of the cognitive impairment market. Globally increasing healthcare expenditure allows for greater accessibility to diagnostic tools, medications, and treatments for cognitive impairments associated with Parkinson’s disease and dementia. Integration of technology, such as telemedicine and remote monitoring, improves patient care and access to cognitive impairment interventions fostering market expansion.
Global Cognitive Impairment in Parkinson’s Disease & Dementia Market – Restraints
The cognitive impairment market in Parkinson’s disease and dementia faces constraints due to a lack of definitive treatment options for Parkinson’s disease and dementia, limiting the ability to address the root cause of cognitive decline effectively. The high cost associated with research and development and clinical trials for cognitive impairment treatments poses a significant restraint, potentially limiting the availability of affordable solutions. According to the National Center for Biotechnology Information (NCBI), the treatment cost per patient is approximately USD 37, 481 Stringent regulatory requirements and lengthy approval processes for new drugs and therapies can impede market growth by delaying the introduction of innovative treatments to the market. The stigma surrounding cognitive impairments and a general lack of awareness can result in delayed diagnosis and treatment, hindering the market’s potential for early intervention and management. Adverse side effects with certain medications used in the treatment of cognitive impairment may lead to patient reluctance, impacting adherence to prescribed therapies and limiting market growth. Ethical considerations related to clinical trials and research involving vulnerable populations, such as those with cognitive impairments, can pose challenges and slow down the pace of advancements in the field. Disparities in healthcare access, especially in lower-income regions, may limit the reach of cognitive impairment interventions, hindering market growth in certain technologies.
Global Cognitive Impairment in Parkinson’s Disease & Dementia Market – Opportunities
Opportunities arise with the ongoing developments in precision medicine, allowing for personalized treatment approaches tailored to the specific characteristics of individuals with cognitive impairments in Parkinson’s disease and dementia. The identification of novel biomarkers presents opportunities for early and accurate diagnosis, enabling timely intervention and treatment in the cognitive impairment Parkinson’s disease and dementia market. The integration of digital health solutions, such as mobile apps and wearable devices, provides opportunities for remote monitoring. Patient engagement, real-time data collection in the management of cognitive impairment in Parkinson’s disease and dementia market.
Global Cognitive Impairment in Parkinson’s Disease & Dementia Market – Geographical Insight
The market for cognitive impairment in Parkinson’s disease and dementia is segmented into regions such as North America, Latin America, Europe, Asia-Pacific, the Middle East & Africa. North America is the largest market for cognitive impairment in Parkinson’s disease and dementia due to the high prevalence of Parkinson’s disease and dementia, well-established healthcare infrastructure, and substantial investment in research and development. European countries contribute significantly to the market, with increasing awareness, advanced healthcare systems, and rising aging populations, creating a conducive environment for the growth of cognitive impairment interventions. The Asia-Pacific region presents substantial growth opportunities, fueled by a large elderly population, changing demographics, and improving healthcare access, leading to increased demand for cognitive impairment solutions.
Global Cognitive Impairment in Parkinson’s Disease & Dementia Market – Key Development
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