Global Acute Graft Versus Host Disease [GvHD] Treatment Market – Overview
Graft versus host disease [GvHD] is a systemic disorder that occurs when the graft’s immune cells recognize the host cells as foreign cells and therefore attack the recipient’s body cells. The graft represents the transplanted or donated tissues and the host cells are the recipient tissues. Graft versus host disease occurs in situations like allogeneic bone transplantation, transplantation of solid organs that are rich in lymphoid cells, and transfusion of un-irradiated blood. Other important factors that determine the severity of the disorder are donor-host factors, stem-cell source factors, immune modulation factors, chemotherapy, and radiation therapy. Acute graft versus host disease can be classified into acute GvHD, persistent GvHD, classic GvHD, and overlap syndrome. Acute GvHD can occur in up to 50% of patients receiving hematopoietic stem cell transplantation (HCT) from a human leukocyte antigen (HLA)- matched siblings. The incidence of chronic GvHD ranges from 6% to 80%.
Treatment of acute graft versus host disease depends on the severity of symptoms and organs involved. Most treatments involve a focus on the immunosuppression of donor T cells. Cyclosporine and methotrexate are the commonly used combination in the treatment. Corticosteroids are the most used medication in the treatment of acute graft versus host disease. Grade 1 GvHD is usually treated with topical steroids. Grade 2 or higher GvHD requires the addition of systemic corticosteroids like methylprednisolone.
Global Acute Graft Versus Host Disease [GvHD] Treatment Market – Competitive Insight
On May 22, 2023, Ironwood entered into a definitive agreement to acquire VectivBio, a clinical-stage biotech company pioneering novel treatments for severe rare gastrointestinal diseases.
On September 8, 2021, Sanofi enhanced its transplant portfolio with a USD 1.9 billion Kadmon acquisition.
Some of the Key Players in the Global Acute Graft Versus Host Disease [GvHD] Treatment markets Include –
Global Acute Graft Versus Host Disease [GvHD] Treatment Market – Growth Drivers
According to the data provided by WHO, up to the year 2050, the proportion of the geriatric population i.e. elderly population will nearly double from 12% to 22%. By 2030, 1 in every 6 people in the world will be aged 60 years or above. This rise in the elderly population indirectly leads to an increase in chronic disorders like cancer which involves stem cell transplantation thus leading to GvHD. These growths in GvHD are likely the growth drivers in the particular market. Cancer is the leading cause of death, accounting for nearly 10 million deaths in 2020 worldwide, which is stated by WHO in one of its articles. High-dose chemotherapy may lead to tissue damage and thus increase the ability of immune cells in the graft to recognize host antigen thus increasing the incidence of acute graft versus host disease. Thus, the increase in cancer patients will ultimately lead to growth in a particular market. Again, the development of new drugs in the treatment of acute graft versus host disease acts as another driver in the GvHD market.
Global Acute Graft Versus Host Disease [GvHD] Treatment Market – Restraints
The main medications used in the treatment of acute graft versus host disease are corticosteroids. However, corticosteroids can have severe adverse effects like steroid myopathy. Steroid myopathy incidence is as high as 41% in acute GvHD. Thus, the use of steroids in the treatment of acute graft versus host disease can act as a major restraint in the particular market. There have been limited treatment options for GvHD. Hence the cost of clinical trials is high, i.e. high investment in the particular market may lead to setbacks for the players in the particular market. Again, allergic reactions have been observed in the treatment of acute graft versus host disease, which again is a restraint for the particular market.
Global Acute Graft Versus Host Disease [GvHD] Treatment Market – Opportunities
The increase in the geriatric population and the increase in the disorders related to GvHD has led to an increase in the opportunities for the key players to invest in the graft versus host disease treatment market. An increase in the development of targeted therapies like biomarkers-based approaches provides another opportunity for the key players to bloom in the particular market. An increase in the government initiatives for awareness regarding acute versus host disease also leads to making of new opportunities in the particular market.
Global Acute Graft Versus Host Disease [GvHD] Treatment Market – Geographical Insight
The market for acute graft versus host disease [GvHD] treatment is segmented into regions such as North America, Latin America, Europe, Asia-Pacific, the Middle East & Africa. North America is the largest market for acute graft versus host disease [GvHD] treatment due to well-established healthcare infrastructure facilities and widespread diagnosis and treatment. Presence of key market players contributing to research and development in the region. In Europe, increasing awareness of cardiovascular diseases and the growing elderly population contribute to the prevalence of acute graft versus host disease [GvHD] treatment. Advanced healthcare systems support timely diagnosis and treatment. Asia-Pacific is another prominent market for the acute graft versus host disease [GvHD] treatment market. The increase in the cases of cancer in the region makes it another prominent market for GvHD.
Global Acute Graft Versus Host Disease [GvHD] Treatment Market – Key Development
Research Methodology: Aspects
Market research is a crucial tool for organizations aiming to navigate the dynamic landscape of customer preferences, business trends, and competitive landscapes. At Cognizance Market Research, acknowledging the importance of robust research methodologies is vital to delivering actionable insights to our clientele. The significance of such methodologies lies in their capability to offer clarity in complexity, guiding strategic management with realistic evidence rather than speculation. Our clientele seek insights that excel superficial observations, reaching deep into the details of consumer behaviours, market dynamics, and evolving opportunities. These insights serve as the basis upon which businesses craft tailored approaches, optimize product offerings, and gain a competitive edge in an ever-growing marketplace.
The frequency of information updates is a cornerstone of our commitment to providing timely, relevant, and accurate insights. Cognizance Market Research adheres to a rigorous schedule of data collection, analysis, and distribution to ensure that our reports reflect the most current market realities. This proactive approach enables our clients to stay ahead of the curve, capitalize on emerging trends, and mitigate risks associated with outdated information.
Our research process is characterized by meticulous attention to detail and methodological rigor. It begins with a comprehensive understanding of client objectives, industry dynamics, and research scope. Leveraging a combination of primary and secondary research methodologies, we gather data from diverse sources including surveys, interviews, industry reports, and proprietary databases. Rigorous data analysis techniques are then employed to derive meaningful insights, identify patterns, and uncover actionable recommendations. Throughout the process, we remain vigilant in upholding the highest standards of data integrity, ensuring that our findings are robust, reliable, and actionable.
Key phases involved in in our research process are mentioned below:
Understanding Clients’ Objectives:
Extensive Discussions and Consultations:
Industry and Market Segment Analysis:
Target Audience Understanding:
Identifying Challenges and Opportunities:
Grasping Specific Goals:
Data Collection:
Primary Research Process:
Secondary Research Process:
Data Analysis:
The data analysis phase serves as a critical juncture where raw data is transformed into actionable insights that inform strategic decision-making. Through the utilization of analytical methods such as statistical analysis and qualitative techniques like thematic coding, we uncover patterns, correlations, and trends within the data. By ensuring the integrity and validity of our findings, we strive to provide clients with accurate and reliable insights that accurately reflect the realities of the market landscape.
Transformation of Raw Data:
Utilization of Analytical Methods:
Statistical Analysis:
Qualitative Analysis Techniques:
Integrity and Validity Maintenance:
Data Validation:
The final phase of our research methodology is data validation, which is essential for ensuring the reliability and credibility of our findings. Validation involves scrutinizing the collected data to identify any inconsistencies, errors, or biases that may have crept in during the research process. We employ various validation techniques, including cross-referencing data from multiple sources, conducting validity checks on survey instruments, and seeking feedback from independent experts or peer reviewers. Additionally, we leverage internal quality assurance protocols to verify the accuracy and integrity of our analysis. By subjecting our findings to rigorous validation procedures, we instill confidence in our clients that the insights they receive are robust, reliable, and trustworthy.
Importance of Data Validation:
Scrutiny of Collected Data:
Validation Techniques:
Internal Quality Assurance Protocols:
We can customize every report – free of charge – including purchasing stand-alone sections or country-level reports
We help clients to procure the report or sections of the report at their budgeted price. Kindly click on the below to avail
Cognizance market research is continuously guiding customers around the globe towards strategies for transformational growth. Today, businesses have to innovate more than ever before, not just to survive, but to succeed in the future
© 2023 All rights Reserved. Cognizance Market Research