Search
report cover1

Downstream Processing Market - Global Industry, Analysis, Size, Share, Growth, Trends, and Forecasts 2024-2032

Global Downstream Processing Market – Overview

The downstream processing industry was estimated to be worth US$6.7 billion globally in 2019. It is anticipated to grow quickly between 2020 and 2030. Following the fermentation process, several steps in the downstream processing process are carried out to recover and purify the desired products. It includes product isolation, purification, polishing, and elimination of insoluble materials. The demand for COVID-19 vaccines, the introduction of new products and solutions for microbial fermentation, the development of new biotherapeutics with smaller molecular weight, and the rise in incidence rates of chronic disorders with significant unmet medical needs are driving the global downstream processing market.

All biological platforms for the manufacture of biopharmaceutical proteins produce an initially turbid extract that must be clarified to avoid fouling-sensitive media such as chromatography resins. Clarification is more challenging if the feed stream contains large amounts of dispersed particles because these rapidly clog the filter media typically used to remove suspended solids. Charged polymers (flocculants) can increase the apparent size of the dispersed particles by aggregation, facilitating the separation of solids and liquids, and thus reducing process costs. However, many different factors can affect the behavior of flocculants, including the pH and conductivity of the medium, the size and charge distribution of the particulates, and the charge density and molecular mass of the polymer. Importantly, these properties can also affect the recovery of the target protein and the overall safety profile of the process.

Global Downstream Processing Market-Competitive Insights

On 14 June 2022, Merck collaborated with Agilent Technologies to reduce the industry gap in process analytical technologies (PAT) for downstream processing. Under the collaboration, the companies combine Merck’s bioprocess portfolio with Agilent Technologies’ advanced analytical products to extend real-time monitoring and automated process control of critical process parameters (CPPs) and critical quality attributes (CQAs) in downstream processing (DSP).

On May 19, 2022, Sartorius began focusing on the growth of its global production capacity with the expansion of its manufacturing site in Tunisia.

On March 19, 2020, Eppendorf AG acquired Koki Holdings Co., Ltd. This acquisition enabled the company to enhance the centrifuge business and consolidate its market position.

Some of the Key Players in the Global Downstream Processing Market Includes –

  • BoehringerIngelheim
  • Danaher Corporation
  • Sartorius Stedium Biotech S.A
  • GE Healthcare
  • Merck Millipore
  • Eppendorf AG
  • 3M Company
  • Thermo Fisher Scientific Inc
  • Finesse Solutions Inc
  • Lonza Group

Global Downstream Processing Market – Growth drivers

The adoption of both upstream and downstream processing equipment is expected to be driven by the development of new biotherapeutics with lower molecular weights. Shortly, it is anticipated that the use of these systems for the synthesis of tiny peptide fragments, recombinant proteins, antibody fragments, and components of antibody-drug conjugates (ADCs) will rise. The demand for more adaptable small-to-medium capacity production is expected to increase with the introduction of tailored medications and a diversified product range. To generate these biotherapeutics, biopharmaceutical producers can use single-use, small-scale systems with a capacity of 100-500 liters instead of massive fermenters. Therefore, it is anticipated that throughout the projected period, the development of new biotherapeutics with lower molecular weight will increase the worldwide downstream processing market.

Global Downstream Processing Market -Restraints

The cost of separation and purification often makes up more than half of the overall process cost. To build a cost-effective bioprocess, the downstream process is carefully examined. Numerous separation and purification procedures have been combined to achieve the requisite degree of purity, which has increased the cost of the downstream process. Even though the efficiency of each stage is satisfactory, the system’s extensive steps result in an increase in equipment costs as well as a reduction in the process’ overall separation efficiency. The monitoring and control of bioprocesses, such as downstream processing, have become more complex as a result of production process advancements, particularly in the biopharmaceutical and nutraceutical industries, and the limitations of some modern and some classical control system techniques are now becoming evident. The above-mentioned factors pose a restrictive impact on the downstream processing industry and call for prompt attention toward optimization techniques for a smooth process flow.

Global Downstream Processing Market -Opportunities

It is most likely the development of new biotherapeutics with lower molecular weights that are driving the use of both upstream and downstream processing technology. Shortly, these techniques will likely be applied more often to the production of small peptide fragments, recombinant proteins, antibody fragments, and antibody-drug conjugate (ADC) components. It is projected that the development of innovative biotherapeutics with a reduced molecular weight will drive the worldwide downstream processing market by generating lucrative prospects.

Global Downstream Processing Market-Geographical Insights

The Global Downstream Processing Market is segmented by geography into North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa. North America dominated the market and accounted for the greatest revenue share of more than 35 percent in 2021. In addition, the region has seen large collaboration activities with healthcare companies that are investing heavily in the research and development of biopharmaceuticals and vaccines. These activities have taken place. In addition, the most important companies that are currently active in the market are increasing their influence in this area. For example, Thermo Fisher Scientific Inc. only recently made public its intention to increase the size of its clinical research facilities in the city of Richmond, Virginia, by investing $97 million. From 2020 to 2030, the Asia Pacific downstream processing industry is projected to grow at a rapid compound annual growth rate (CAGR). The biopharmaceutical industry in China and India is growing quickly, which has led to the market’s expansion in the area. Leading companies are also concentrating on establishing their presence in new regions.

Global Downstream Processing Market– Key Development

  • On April 20, 2022, Thermo Fisher Scientific opened a bioprocessing manufacturing site in Ogden, Utah, for the development of biologics and vaccines.
  • On May 19, 2022, Sartorius began focusing on the growth of its global production capacity with the expansion of its manufacturing site in Tunisia.
  • On June 13, 2022, Bio-Rad introduced the CHT™ prepacked Foresight Pro Columns to serve downstream process-scale chromatography applications throughout all stages of biological drug research and manufacture.
Complete the form below and we'll get back to you shortly
Table of Content
Complete the form below and we'll get back to you shortly
Sample

Research Methodology: Aspects

Market research is a crucial tool for organizations aiming to navigate the dynamic landscape of customer preferences, business trends, and competitive landscapes. At Cognizance Market Research, acknowledging the importance of robust research methodologies is vital to delivering actionable insights to our clientele. The significance of such methodologies lies in their capability to offer clarity in complexity, guiding strategic management with realistic evidence rather than speculation. Our clientele seek insights that excel superficial observations, reaching deep into the details of consumer behaviours, market dynamics, and evolving opportunities. These insights serve as the basis upon which businesses craft tailored approaches, optimize product offerings, and gain a competitive edge in an ever-growing marketplace.

The frequency of information updates is a cornerstone of our commitment to providing timely, relevant, and accurate insights. Cognizance Market Research adheres to a rigorous schedule of data collection, analysis, and distribution to ensure that our reports reflect the most current market realities. This proactive approach enables our clients to stay ahead of the curve, capitalize on emerging trends, and mitigate risks associated with outdated information.

Our research process is characterized by meticulous attention to detail and methodological rigor. It begins with a comprehensive understanding of client objectives, industry dynamics, and research scope. Leveraging a combination of primary and secondary research methodologies, we gather data from diverse sources including surveys, interviews, industry reports, and proprietary databases. Rigorous data analysis techniques are then employed to derive meaningful insights, identify patterns, and uncover actionable recommendations. Throughout the process, we remain vigilant in upholding the highest standards of data integrity, ensuring that our findings are robust, reliable, and actionable.

Key phases involved in in our research process are mentioned below:

slide1

Understanding Clients’ Objectives:

Extensive Discussions and Consultations:

  • We initiate in-depth discussions and consultations with our clients to gain a comprehensive understanding of their objectives. This involves actively listening to their needs, concerns, and aspirations regarding the research project.
  • Through these interactions, we aim to uncover the underlying motivations driving their research requirements and the specific outcomes they hope to achieve.

Industry and Market Segment Analysis:

  • We invest time and effort in comprehensively understanding our clients’ industry and market segment. This involves conducting thorough research into market trends, competitive dynamics, regulatory frameworks, and emerging opportunities or threats.
  • By acquiring a deep understanding of the broader industry landscape, we can provide context-rich insights that resonate with our clients’ strategic objectives.

Target Audience Understanding:

  • We analyze our clients’ target audience demographics, behaviors, preferences, and needs to align our research efforts with their consumer-centric objectives. This entails segmenting the audience based on various criteria such as age, gender, income level, geographic location, and psychographic factors.
  • By understanding the nuances of the target audience, we can tailor our research methodologies to gather relevant data that illuminates consumer perceptions, attitudes, and purchase intent.

slide2

Identifying Challenges and Opportunities:

  • We proactively identify the challenges and opportunities facing our clients within their respective industries. This involves conducting SWOT (Strengths, Weaknesses, Opportunities, Threats) analyses and competitive benchmarking exercises.
  • By identifying potential obstacles and growth drivers, we can provide strategic recommendations that help our clients navigate complexities and capitalize on emerging opportunities effectively.

Grasping Specific Goals:

  • We delve into the intricacies of our clients’ objectives to gain clarity on the specific goals they aim to accomplish through the research. This entails understanding their desired outcomes, such as market expansion, product development, or competitive analysis.
  • By gaining a nuanced understanding of our clients’ goals, we can tailor our research approach to address their unique challenges and opportunities effectively.

Data Collection:

slide3

Primary Research Process:

  • Surveys: We design and administer surveys tailored to capture specific information relevant to our clients’ objectives. This may involve employing various survey methodologies, such as online, telephone, or face-to-face interviews, to reach target audiences effectively.
  • Interviews: We conduct structured or semi-structured interviews with key stakeholders, industry experts, or target consumers to gather in-depth insights and perspectives on relevant topics. These interviews allow us to probe deeper into specific issues and uncover valuable qualitative data.
  • Focus Groups: We organize focus group discussions with carefully selected participants to facilitate interactive discussions and gather collective opinions, attitudes, and preferences. This qualitative research method provides rich contextual insights into consumer behaviors and perceptions.
  • Observations: We conduct observational research by directly observing consumer behaviors, interactions, and experiences in real-world settings. This method enables us to gather objective data on consumer actions and reactions without relying on self-reported information.

Secondary Research Process:

  • Literature Review: We conduct comprehensive literature reviews to identify existing studies, academic articles, and industry reports relevant to the research topic. This helps us gain insights into previous research findings, theoretical frameworks, and best practices.
  • Industry Reports: We analyze industry reports published by reputable trade associations (whitepapers, research studies, etc.), and government agencies (U.S. Census Bureau, Bureau of Labor Statistics, and Securities and Exchange Commission etc.) to obtain macro-level insights into market trends, competitive landscapes, and industry dynamics.
  • Government Publications: We review government publications, such as economic reports, regulatory documents, and statistical databases, to gather relevant data on demographics, market size, consumer spending patterns, and regulatory frameworks.
  • Online Databases: We leverage online databases, such as industry portals, and academic repositories (PubMed Central (PMC), ScienceDirect, SSRN (Social Science Research Network), Directory of Open Access Journals (DOAJ), NCBI, etc.), to access a wide range of secondary data sources, including market statistics, financial data, and industry analyses.

slide4

slide5

Data Analysis:

The data analysis phase serves as a critical juncture where raw data is transformed into actionable insights that inform strategic decision-making. Through the utilization of analytical methods such as statistical analysis and qualitative techniques like thematic coding, we uncover patterns, correlations, and trends within the data. By ensuring the integrity and validity of our findings, we strive to provide clients with accurate and reliable insights that accurately reflect the realities of the market landscape.

slide6

Transformation of Raw Data:

  • Upon collecting the necessary data, we transition into the data analysis phase, where raw data is processed and transformed into actionable insights. This involves organizing, cleaning, and structuring the data to prepare it for analysis.

Utilization of Analytical Methods:

  • Depending on the research objectives, we employ a diverse range of analytical methods to extract meaningful insights from the data. These methods include statistical analysis, trend analysis, regression analysis, and qualitative coding.

Statistical Analysis:

  • Statistical tools are instrumental in uncovering patterns, correlations, and trends within the data. By applying statistical techniques such as descriptive statistics, hypothesis testing, and multivariate analysis, we can discern relationships and derive valuable insights.

Qualitative Analysis Techniques:

  • In addition to quantitative analysis, we leverage qualitative analysis techniques to gain deeper insights from qualitative data sources such as interviews or open-ended survey responses. One such technique is thematic coding, which involves systematically categorizing and interpreting themes or patterns within qualitative data.

Integrity and Validity Maintenance:

  • Throughout the analysis process, we maintain a steadfast commitment to upholding the integrity and validity of our findings. This entails rigorous adherence to established methodologies, transparency in data handling, and thorough validation of analytical outcomes.

Data Validation:

The final phase of our research methodology is data validation, which is essential for ensuring the reliability and credibility of our findings. Validation involves scrutinizing the collected data to identify any inconsistencies, errors, or biases that may have crept in during the research process. We employ various validation techniques, including cross-referencing data from multiple sources, conducting validity checks on survey instruments, and seeking feedback from independent experts or peer reviewers. Additionally, we leverage internal quality assurance protocols to verify the accuracy and integrity of our analysis. By subjecting our findings to rigorous validation procedures, we instill confidence in our clients that the insights they receive are robust, reliable, and trustworthy.

slide7

Importance of Data Validation:

  • Data validation is the final phase of the research methodology, crucial for ensuring the reliability and credibility of the findings. It involves a systematic process of reviewing and verifying the collected data to detect any inconsistencies, errors, or biases.

Scrutiny of Collected Data:

  • The validation process begins with a thorough scrutiny of the collected data to identify any discrepancies or anomalies. This entails comparing data points, checking for outliers, and verifying the accuracy of data entries against the original sources.

Validation Techniques:

  • Various validation techniques are employed to ensure the accuracy and integrity of the data. These include cross-referencing data from multiple sources to corroborate findings, conducting validity checks on survey instruments to assess the reliability of responses, and seeking feedback from independent experts or peer reviewers to validate the interpretation of results.

Internal Quality Assurance Protocols:

  • In addition to external validation measures, internal quality assurance protocols are implemented to further validate the accuracy of the analysis. This may involve conducting internal audits, peer reviews, or data validation checks to ensure that the research process adheres to established standards and guidelines.
- Get Started -

Get insights that lead to new growth opportunities

Need a Custom Report?

We can customize every report – free of charge – including purchasing stand-alone sections or country-level reports

Want to Buy a Report but have a Limited Budget?

We help clients to procure the report or sections of the report at their budgeted price. Kindly click on the below to avail

Business Development

small c popup.png
Buy Now
small c popup.png
Complete the form below and we'll get back to you shortly
Customization
small c popup.png
Complete the form below and we'll get back to you shortly
Discount
small c popup.png
Complete the form below and we'll get back to you shortly
Ask an Expert